Resumen

Although the production of antigen-specific antibodies has been the originally accepted function of B-cells during immune responses, specific subsets that can negatively regulate inflammation, designated regulatory B-cells (Bregs), have been identified recently. These immunosuppressive cells support tolerance, mainly through the production of interleukin 10 and other unconventional factors. There have been emerging data suggesting their importance in diverse normal and pathologic processes. Novel and in development B-cell targeted therapies seem to be ideal treatments for different types of diseases such as cancer and allergy. Here, we discuss the current knowledge on the implication of Bregs in autoimmunity-related diseases, highlighting the importance of these cells for the development of novel strategies in the treatment of these pathologies.

Palabras clave: B-cell B regulatory cells autoimmunity.

2017-10-31   |   511 visitas   |   2 valoraciones

Vol. 69 Núm.5. Septiembre-Octubre 2017 Pags. 243-246 Rev Invest Clin 2017; 69(5)